-
Views
-
Cite
Cite
Blaise Genton, Valérie D'Acremont, Intranasal versus Injectable Influenza Vaccine, Clinical Infectious Diseases, Volume 39, Issue 5, 1 September 2004, Page 754, https://doi.org/10.1086/422879
Close - Share Icon Share
Extract
Sir—We read with interest the article by Sendi et al. [1] on the safety of intranasal and injectable influenza vaccines in a working Swiss population. They report that, of the 13% of the subjects who wished to be vaccinated, the nasal route was the preferred route of administration for 97%. This is a striking finding, and we would like to know what information was provided to the volunteers for them to make their choices. Indeed, at that time (winter 2000), to our knowledge, there were no published safety data with side-by-side comparisons of the 2 types of vaccines; more importantly, there were no data on immunogenicity (protective antibody titers) and, therefore, on the efficacy for humans of the specific intranasal vaccine used (Nasalflu; Berna Biotech AG). Thus, we wonder on what grounds the subjects mentioned “increased efficacy” as a reason for choosing the nasal spray (23% in table 1 of [1]). Was that information suggested by the information leaflet?
