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Rodger D. MacArthur, Mark Miller, Timothy Albertson, Edward Panacek, David Johnson, Leah Teoh, William Barchuk, Adequacy of Early Empiric Antibiotic Treatment and Survival in Severe Sepsis: Experience from the MONARCS Trial, Clinical Infectious Diseases, Volume 38, Issue 2, 15 January 2004, Pages 284–288, https://doi.org/10.1086/379825
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Abstract
As part of the Monoclonal Anti-TNF: A Randomized Controlled Sepsis (MONARCS) trial, which enrolled patients with suspected sepsis, we sought to determine whether adequate antibiotic therapy was associated with a decreased mortality rate. The study enrolled 2634 patients, 91% of whom received adequate antibiotic therapy. The mortality rate among patients given adequate antibiotic treatment was 33%, versus 43% among patients given inadequate treatment (P < .001). We conclude that adequate antibiotic therapy results in a significant decrease in the crude mortality rate among patients suspected of sepsis.