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David S. Hong, Kalen L. Jacobson, Issam I. Raad, Marcos de Lima, Paolo Anderlini, Gregory N. Fuller, Cindy Ippoliti, Rita M. Cool, Norman E. Leeds, Aida Narvios, Xiang Y. Han, Anthony Padula, Richard E. Champlin, Chitra Hosing, West Nile Encephalitis in 2 Hematopoietic Stem Cell Transplant Recipients: Case Series and Literature Review, Clinical Infectious Diseases, Volume 37, Issue 8, 15 October 2003, Pages 1044–1049, https://doi.org/10.1086/378278
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Abstract
Most human cases of West Nile virus infection are acquired via bites from an infected mosquito. In some cases, infection may also be transmitted by infected blood products or transplanted organs. There have been recent publications suggesting that chemotherapy and immunosuppression may increase a person's risks of developing central nervous system disease if the person is infected with the West Nile virus. Because patients undergoing hematopoietic stem cell transplantation not only are immunocompromised, but also receive multiple blood products, they are at a particularly high risk for acquiring symptomatic disease if exposed to the West Nile Virus. We describe here 2 patients who underwent hematopoietic transplantation at our institution and subsequently developed fatal West Nile virus infections.
- encephalitis
- bites
- chemotherapy regimen
- central nervous system dysfunction
- hematopoietic stem cell transplantation
- culicidae
- immunocompromised host
- west nile fever
- west nile virus
- therapeutic immunosuppression
- natural immunosuppression
- infections
- transplantation
- transplanted organ
- west nile viral infections
- blood products