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Y. Weil, Y. Mattan, M. Liebergall, G. Rahav, Brucella Prosthetic Joint Infection: A Report of 3 Cases and a Review of the Literature, Clinical Infectious Diseases, Volume 36, Issue 7, 1 April 2003, Pages e81–e86, https://doi.org/10.1086/368084
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Abstract
We report 3 cases of Brucella melitensis infection of prosthetic hips and knees, and we summarize data about 4 cases reported in the literature. Six of the 7 affected patients were men. The median duration from prosthesis implantation to the onset of symptoms was 38.7 months. Five patients had only local symptoms. Preoperative joint aspirates yielded negative culture results for 3 patients, and blood culture results were negative for 6 patients. Excisional arthroplasty was the initial intervention for 3 patients. Three others responded well to medical therapy alone. One patient had relapse while receiving tetracycline and underwent total hip replacement. All patients were treated with combined antibiotic therapy for 6 weeks to 19 months. All had favorable long-term responses. The 3 patients we treated underwent a 2-staged resection arthroplasty. Antibiotics alone can be used to treat Brucella prosthetic joint infection, but loosening of the joint and clinical or microbiological failure must be treated with a 2-staged excisional arthroplasty and 3 months of treatment with doxycycline and rifampicin.
- antibiotics
- rifampin
- doxycycline
- combined antibiotics
- brucella
- knee region
- preoperative care
- prosthesis implantation
- brucella melitensis infections
- hip joint prosthesis
- hip replacement arthroplasty
- tetracycline
- resection arthroplasty
- prosthetic joint infections
- blood culture
- symptom onset
- medical management