Extract

Antimicrobial resistance has become an international problem of momentous proportions. To help clinicians provide effective antimicrobial therapy for bacterial pathogens of increasing diversity, the National Committee for Clinical Laboratory Standards (NCCLS) has put forth considerable efforts to keep pace with accurate methods for detection of resistance in clinical isolates. Drs. Jorgensen and Ferraro have headed the NCCLS's Subcommittee on Antimicrobial Susceptibility Testing throughout the 1990s as the Subcommittee has endeavored to develop practical, standardized methods for resistance testing based on expanding knowledge about mechanisms of known and emerging resistance. In the following article, they provide a masterful, succinct summary of the current best methods for detection of important resistance mechanisms in staphylococci, enterococci, Enterobacteriaceae, and fastidious bacteria. They have also provided an up-to-date bibliography, which includes references to the primary source documents of the NCCLS that are required for reliable performance of testing by clinical micro-biology laboratories, on which infectious disease clinicians depend.

You do not currently have access to this article.