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Robert Fekety, Joseph Silva, John Armstrong, Maria Allo, Robert Browne, John Ebright, Rodney Lusk, Gary Rifkin, Renu Toshniwal, Treatment of Antibiotic-Associated Enterocolitis with Vancomycin, Reviews of Infectious Diseases, Volume 3, Issue Supplement_2, November-December 1981, Pages S273–S281, https://doi.org/10.1093/clinids/3.Supplement_2.S273
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Abstract
Studies in humans and hamsters have shown that Clostridium difficile is the most important cause of antibiotic-associated colitis. A toxin produced by the organism is responsible for the disease and can be detected in the stools of patients. Proctosigmoidoscopy is the quickest, as well as the most accurate, way to establish the diagnosis. The organisms are very susceptible to vancomycin, which is highly effective in treatment of the disease and also remarkably free of serious adverse effects when given orally.