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E. Könönen, S. Nyfors, J. Máttö, S. Asikainen, H. Jousimies Somer, β-Lactamase Production by Oral Pigmented Prevotella Species Isolated from Young Children, Clinical Infectious Diseases, Volume 25, Issue Supplement_2, January-February 1988, Pages S272–S274, https://doi.org/10.1086/516208
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Abstract
The frequency of β-lactamase production by oral pigmented Prevotella species isolated from 23 healthy young children and the minimal inhibitory concentrations (MICs) for 186 available β-lactamasepositive isolates were examined by using the chromogenic cephalosporin disk test (AB BIODISK, Solna, Sweden) and the Etest (AB BIODISK) and/or the agar dilution method of the National Committee for Clinical Laboratory Standards (Villanova, PA, USA), respectively. b-Lactamase-positive Prevotella melaninogenica strains were isolated from all children, and more than two-thirds of the Prevotella denticola and Prevotella loescheii strains isolated from the children were β-lactamase-positive. The blactamase- producing Prevotella intermedia group consisted of Prevotella nigrescens and the P. intermedia/ P. nigrescens-like organism (PINLO); P. intermedia was not found. Only two P. nigrescens isolates but most of the PINLO isolates produced β-lactamase. The MICs for β-lactamase-producing strains varied between 0.38 and 64 μ/mL. β-Lactamase production by oral pigmented Prevotella species colonizing young children is already frequent. The phenomenon should be taken into account in the treatment of pediatric anaerobic infections of oral origin.
