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Antti Nissinen, Maija Leinonen, Pentti Huovinen, Elja Herva, Marja-Leena Katila, Sirkka Kontiainen, Oili Liimatainen, Sinikka Oinonen, Aino K. Takala, P. Helena Mäkelä, Antimicrobial Resistance of Streptococcus pneumoniae in Finland, 1987–1990, Clinical Infectious Diseases, Volume 20, Issue 5, May 1995, Pages 1275–1280, https://doi.org/10.1093/clinids/20.5.1275
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Abstract
A nationwide survey of the prevalence of antimicrobial resistance among Streptococcus pneumoniae isolates from the middle ear fluid of children with acute otitis media (639 strains) and from throat-swab samples of healthy children (149 strains) was conducted in Finland during 1987–1990. The MICs of penicillin, cephalothin, cefaclor, erythromycin, trimethoprim, and co-trimoxazole were determined by the agar dilution method. Low-level resistance to penicillin (MIC, 0.1–1 µg/mL) was found in 1.7% of the otitis-related and 1.3% of the healthy-carrier strains. No highly penicillin-resistant strains (MIC, ⩾2 µg/mL) were found. Six multiresistant strains were detected, three of them possibly belonging to a previously identified clone present in Finland since 1985. Eighty-five percent of the resistant otitis-related strains, including 9 of the 11 moderately penicillin-resistant strains (4 of which were multiresistant), belonged to the three most common serogroups (6, 19, and 23).
- erythromycin
- penicillin
- otitis media, acute
- agar
- cefaclor
- cephalothin
- child
- clone cells
- drug resistance, microbial
- finland
- otitis
- otitis media with effusion
- penicillin resistance
- streptococcus pneumoniae
- trimethoprim
- trimethoprim-sulfamethoxazole combination
- well child
- throat swab
- dilution technique
- dilute (action)
- malnutrition-inflammation-cachexia syndrome
- serogroup