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Tina Q. Tan, Hannes Vogel, Barry R. Tharp, Clark L. Carrol, Sheldon L. Kaplan, Presumed Central Nervous System Whipple's Disease in a Child: Case Report, Clinical Infectious Diseases, Volume 20, Issue 4, April 1995, Pages 883–889, https://doi.org/10.1093/clinids/20.4.883
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Abstract
Whipple's disease is a rare, chronic, multisystem illness that is pathologically characterized by the accumulation of macrophages in the involved tissue that have a positive periodic acid-Schiff reaction. It is typically seen in middle-aged white men, and only four cases involving persons younger than 15 years of age have been reported. CNS Whipple's disease without intestinal manifestations is rare; only six cases have been reported in the literature, all involving adults. We report the case of a young boy with clinical, laboratory, radiographic, and pathological signs and symptoms consistent with CNS Whipple's disease who responded to therapy with trimethoprim-sulfamethoxazole.