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Alexander G. Vandevelde, Stephen G. Jenkins, Philip R. Hardy, Sclerosing Osteomyelitis and Actinomyces naeslundii Infection of Surrounding Tissues, Clinical Infectious Diseases, Volume 20, Issue 4, April 1995, Pages 1037–1039, https://doi.org/10.1093/clinids/20.4.1037
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Abstract
We present the case of a young man with chronic Actinomyces naeslundii infection in the lower leg who underwent a below-the-knee amputation after unsuccessful attempts at diagnosing and eradicating the infection. Actinomycetic organisms from environmental sources can engender a dense fibrotic tissue response without fistulae. Such a response led to a painful, sclerosing, nonsuppurative infection of the bone and surrounding tissues in our patient. This clinical picture, at least the bony and periosteal reaction, was compatible with Garrè's osteomyelitis.