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Joyce D. Gryboski, Samuel Kocoshis, Effect of Bismuth Subsalicylate on Chronic Diarrhea in Childhood: A Preliminary Report, Reviews of Infectious Diseases, Volume 12, Issue Supplement_1, January-February 1990, Pages S36–S40, https://doi.org/10.1093/clinids/12.Supplement_1.S36
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Abstract
Stools collected from 39 infants and children with chronic nonspecific diarrhea and from 10 age-matched controls were examined for bile acid content with use of gas-liquid chromatography. Values were correlated with stool color. Mean concentration of bile acids in green stools (7.7 ± 1.52 mg/g dry weight) was significantly higher than that in brown stools (3.76 ± 0.7 mg/g dry weight) and in control stools (1.42 ± 0.35 mg/g dry weight). In patients with green diarrhea, treatments with cholestyramine and bismuth subsalicylate (Pepto-Bismol) were equally effective in decreasing stool frequency, with the latter being more effective in decreasing water content. Patients with brown stools had an insignificant response to therapy.