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Andrew R. Pachner, Neurologic Manifestations of Lyme Disease, the New “Great Imitator”, Reviews of Infectious Diseases, Volume 11, Issue Supplement_6, September-October 1989, Pages S1482–S1486, https://doi.org/10.1093/clinids/11.Supplement_6.S1482
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Abstract
The causative agent of Lymedisease, Borrelia burgdorferi, is a highly neurotropic organism that not only can produce symptomatic neurologic disease but also can exist dormant within the central nervous system (CNS) for long periods. Two distinct types of neuroborreliosis occur at different stages of Lyme disease. Second-stage Lyme meningitis resembles aseptic meningitis and is often associated with facial palsies, peripheral nerve involvement, and/or radiculopathies. Lyme meningitis may be the first evidence of Lyme disease, occurring without a history of erythema chronicum migrans or flu-like illness. Third-stage parenchymal involvement causes a multitude of nonspecific CNS manifestations that can be confused with conditions such as multiple sclerosis, brain tumor, and psychiatric derangements. Manifestations of eNS parenchymal involvement in Lymedisease are generally associated, however, with a history of erythema chronicum migrans, meningitis, or carditis. Both second- and third-stage Lymeneuroborrelioses are commonly misdiagnosed because they are relatively uncommon and because they mimic many betterknown disorders.
- lyme disease
- aseptic meningitis
- meningitis
- nervous system disorders
- brain tumors
- central nervous system
- facial paralysis
- borrelia burgdorferi
- erythema chronicum migrans
- lyme neuroborreliosis
- multiple sclerosis
- neurologic manifestations
- peripheral nerves
- psychiatry
- radiculopathy
- carditis
- linear sebaceous nevus sequence
- meningitis in lyme disease
- misdiagnosis
- flu-like illness
- cns symptom
