Abstract

We recently explored the expression of CXCR5 on T and B cells from peripheral blood of patients with primary Sjögren’s syndrome (SS). Here we investigated the frequency of CD25+FoxP3+CD4+ regulatory T cells (Tregs) among CXCR5+CD4+ follicular cells in the same cohort of patients. We confirm that the frequency of Tregs among follicular T cells is increased in SS patients and also provide novel data showing an increased frequency of PD-1 expressing cells among CXCR5+FoxP3+CD4+ T cells.

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