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Sir, I read the recent article of Hanganu et al. (2014) entitled ‘Mild cognitive impairment is linked with faster rate of cortical thinning in patients with Parkinson’s disease longitudinally’ with great interest and I would like to comment on some of their important findings.

Hanganu et al. (2014) investigated the longitudinal changes of the cortical and subcortical grey matter in patients with Parkinson’s disease, at the early stages of the illness, with and without mild cognitive impairment. They found a higher rate of cortical thinning in the temporal, occipital, parietal and supplementary motor area, in patients with Parkinson’s disease with mild cognitive impairment compared with both cognitively stable patients and healthy controls. Subcortically, a significant decrease in the volume of the amygdala and nucleus accumbens was observed in the group with Parkinson’s disease with mild cognitive impairment versus both Parkinson’s disease without mild cognitive impairment and healthy controls. Yet, only these two structures showed a significant decrease of grey matter over time in Parkinson’s disease with mild cognitive impairment versus the Parkinson’s disease group without such impairment (Hanganu et al., 2014).

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