...This chapter discusses the high sensitivity of the sense organs, particularly the sensitivity of the human sense of smell. It is shown here that the olfactory cells respond to one single odorous molecule, or at least to a very small number of them. The chapter also discusses special problems...

... of high-sensitivity cardiac troponin. Potential complications with trial design are then discussed using theoretical examples of test/treatment combinations. impact studies assistive approach directive decision approach High-STEACS study high-sensitivity cardiac troponin assistive approach before...

...-cTnI (Vitros) <1 tbd tbd ≥40 tbd Optimal cut-off levels in ng/L for use in the ESC 0/1-hour and 0/2-hour algorithms are assay-specific and listed for all high-sensitivity cardiac troponin (hs-cTn) assays with validated algorithms available. The algorithms for additional assays...

... are therefore potentially relevant to cardiovascular disease risk assessment. These biomarkers are inflammatory (high-sensitivity C-reactive protein and fibrinogen) and thrombotic (homocysteine and Lp-PLA₂). This chapter provides detailed information on both of these groups, providing detail on how...

...This chapter describes the theory and practical applications of coulometric respirometry. Coulometric respirometry is probably the most accurate method for measuring oxygen consumption rates. It is ideal for small animals and has the dual advantages of high sensitivity and the fact that the oxygen...

... a biophysical approach to introduce each cochlear response. The article focuses on the otoacoustic responses of the cochlea, because these responses describe the most vulnerable cochlear mechanism on which high sensitivity depends and which is most commonly found to be disabled in cases of hearing impairment...

... of coulometric respirometry. Coulometric respirometry is probably the most accurate method for measuring oxygen consumption rates. It is ideal for small animals and has the dual advantages of high sensitivity and the fact that the oxygen in the organism’s environment is not depleted, allowing measurements...

..., if the glow can be seen over a wide angle (as is the case with many deep-sea shrimps, for example), this indicates either that there is a large blur circle on the retina, or that the tapetum is situated a long way from the focus. The high sensitivity of most superposition eyes means that they must protect...

...European Society of Cardiology Coronary CT angiography (CCTA) can be a valuable diagnostic tool in suspected acute coronary syndrome without ST segment elevation. Patients in whom the initial clinical work-up, including serial cardiac (high-sensitivity) troponins, remains inconclusive are most...

..., and to optimize patient management and the use of health care resources. New algorithms using high-sensitivity cardiac troponin assays at low cut-offs alone, or in combination with additional biomarkers, allow to establish accelerated rule-out algorithms within 1 or 2 hours. acute coronary syndrome diagnosis...

..., namely its high sensitivity, so that it provides one of the few methods that is entirely suitable for the identification, structural elucidation, and for the quantitative measurement of even trace amounts of the various analytes present in a mixture. Generally, however, and certainly for complex mixtures...