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Neural Plasticity and Cognitive Development: Insights from Children with Perinatal Brain Injury

Online ISBN:
9780190255718
Print ISBN:
9780195389944
Publisher:
Oxford University Press
Book

Neural Plasticity and Cognitive Development: Insights from Children with Perinatal Brain Injury

Joan Stiles,
Joan Stiles

Emeritus Professor of Cognitive Sciences

University of California, San Diego, La Jolla, CA, Emeritus Professor of Cognitive Sciences
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Judy S. Reilly,
Judy S. Reilly

Emeritus Professor of Psychology

San Diego State University, San Diego, CA, Emeritus Professor of Psychology
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Susan C. Levine,
Susan C. Levine

Stella M. Rowley Professor, Departments of Psychology, Comparative Human Development, and Committee on Education; Chair, Department of Psychology

University of Chicago, Chicago, IL, Stella M. Rowley Professor, Departments of Psychology, Comparative Human Development, and Committee on Education; Chair, Department of Psychology
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Doris A. Trauner,
Doris A. Trauner

Professor of Neurosciences and Pediatrics; Chief, Pediatric Neurology

University of California, San Diego School of Medicine; University of California, San Diego School of Medicine and Rady Children's Hospital San Diego, La Jolla, CA, Professor of Neurosciences and Pediatrics; Chief, Pediatric Neurology
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Ruth Nass
Ruth Nass

Professor of Child Neurology, Child and Adolescent Psychiatry, and Pediatrics

New York University, New York, NY, Professor of Child Neurology, Child and Adolescent Psychiatry, and Pediatrics
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Published online:
24 March 2015
Published in print:
14 June 2012
Online ISBN:
9780190255718
Print ISBN:
9780195389944
Publisher:
Oxford University Press

Abstract

The advent of modern neurobiological methods over the last three decades has provided overwhelming evidence that it is the interaction of genetic factors and the experience of the individual that guides and supports brain development. Brains do not develop normally in the absence of critical genetic signaling, and they do not develop normally in the absence of essential environmental input. The key to understanding the origins and emergence of both the brain and behavior lies in understanding how inherited and environmental factors are engaged in the dynamic and interactive processes that define and direct development of the neurobehavioral system. This book focuses on children who suffered focal brain insult (typically stroke) in the pre- or perinatal period which provides a model for exploring the dynamic nature of early brain and cognitive development. In most, though not all, of the cases considered, the injuries affect substantial portions of one cerebral hemisphere, resulting in patterns of neural damage that would compromise cognitive ability in adults. However, longitudinal behavioral studies of this population of children have revealed only mild cognitive deficits, and preliminary data from neural damage functional brain imaging studies suggest that alternative patterns of functional organization emerge in the wake of early injury. This book posits that the capacity for adaptation is not the result of early insult. Rather, it reflects normal developmental processes which are both dynamic and adaptive operating against a backdrop of serious perturbation of the neural substrate.

Disclaimer
Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always … More Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work. Except where otherwise stated, drug dosages and recommendations are for the non-pregnant adult who is not breastfeeding.
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