Stroke Genetics
Stroke Genetics
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Abstract
Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. An increasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently “sporadic” stroke. Stroke Genetics provides an up-to-date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemic stroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggest that genetic factors are also important for the much more common multifactorial stroke; this evidence is reviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing a practical approach to investigating patients with stroke for underlying genetic disorders. Also included is a list of useful websites.
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Front Matter
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1
An introduction to stroke
Hugh S Markus
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2
Genetic principles and techniques
Andrew J Catto andAngela M Carter
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3
Genetic epidemiology of stroke
James F Meschia andRobert D Brown
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4
Genetics of conventional stroke risk factors
Giuseppe A Sagnella
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5
Animal models of stroke: implications for genetic studies of human stroke
Speranza Rubattu and others
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6
Monogenic causes of ischaemic stroke
Martin Dichgans
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7
Polygenic ischaemic stroke including new genetic and statistical approaches
Ahamad Hassan andHugh S Markus
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8
Investigating the genetics of polygenic ischaemic stroke using intermediate phenotypes
Paula Jerrard-Dunne and others
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9
Genetics of intracerebral haemorrhage
Joost Haan
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10
Genetics of subarachnoid haemorrhage and intracranial aneurysms
Wouter I Schievink
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11
Familial cerebral arteriovenous malformations
Pierre Labauge
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12
The genetics of paediatric stroke
Fenella Kirkham andMara Prengler
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13
Investigating a patient with stroke for genetic causes
Hugh S Markus
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14
Useful web sites for stroke genetics
Hugh S Markus
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