Infectious Diseases of Humans: Dynamics and Control
Infectious Diseases of Humans: Dynamics and Control
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Abstract
This book combines mathematical models with extensive use of epidemiological and other data, to achieve a better understanding of the overall dynamics of populations of pathogens or parasites and their human hosts. The authors thus provide an analytical framework for evaluating public health strategies aimed at controlling or eradicating particular infections. With rising concern for programmes of primary health care against such diseases as measles, malaria, river blindness, sleeping sickness, and schistosomiasis in developing countries, and the advent of HIV/AIDS and other `emerging viruses', such a framework is increasingly important. Throughout, the mathematics is used as a tool for thinking clearly about fundamental and applied problems relating to infectious diseases. The book is divided into two major parts, one dealing with microparasites (viruses, bacteria, and protozoans) and the other with macroparasites (helminths and parasitic arthropods). Each part begins with simple models, developed in a biologically intuitive way, and then goes on to develop more complicated and realistic models as tools for public health planning. A major contribution by two of the leaders in the field, this book synthesizes previous work in this rapidly growing area with much new material, combining work scattered between the ecological and medical literature.
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Front Matter
- I Introduction
- 2 A framework for discussing the population biology of infectious diseases
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Part I Microparasites
Roy M Anderson andRobert M May- 3 Biology of host-microparasite associations
- 4 The basic model: statics
- 5 Static aspects of eradication and control
- 6 The basic model: dynamics
- 7 Dynamic aspects of eradication and control
- 8 Beyond the basic model: empirical evidence for inhomogeneous mixing
- 9 Age-related transmission rates
- 10 Genetic heterogeneity
- 11 Social heterogeneity and sexually transmitted diseases
- 12 Spatial and other kinds of heterogeneity
- 13 Endemic infections in developing countries
- 14 Indirectly transmitted microparasites
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Part II Macroparasites
Roy M Anderson andRobert M May- 15 Biology of host-macroparasite associations
- 16 The basic model: statics
- 17 The basic model: dynamics
- 18 Acquired immunity
- 19 Heterogeneity within the human community
- 20 Indirectly transmitted helminths
- 21 Experimental epidemiology
- 22 Parasites, genetic variability, and drug resistance
- 23 The ecology and genetics of host-parasite associations
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End Matter
- Appendix A Static properties of models for host-microparasite interactions
- Appendix B Static aspects of a programme of immunization according to a general age-dependent schedule
- Appendix C Dynamic properties of models for host-microparasite interactions
- Appendix D Age-dependent transmission and WAIFW matrices
- Appendix E Aspects of heterogeneities in host-microparasite interactions
- Appendix F Behavioural heterogeneity and the transmission dynamics of HIV/AIDS and other STDs
- Appendix G Optimal immunization programmes in heterogeneous populations
- Appendix H Mating probabilities and egg output for macroparasites
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