Biophysics of Computation: Information Processing in Single Neurons
Biophysics of Computation: Information Processing in Single Neurons
Cite
Abstract
Neural network research often builds on the fiction that neurons are simple linear threshold units, completely neglecting the highly dynamic and complex nature of synapses, dendrites, and voltage-dependent ionic currents. Biophysics of Computation: Information Processing in Single Neurons challenges this notion, using richly detailed experimental and theoretical findings from cellular biophysics to explain the repertoire of computational functions available to single neurons. The author shows how individual nerve cells can multiply, integrate, or delay synaptic inputs and how information can be encoded in the voltage across the membrane, in the intracellular calcium concentration, or in the timing of individual spikes. Key topics covered include the linear cable equation; cable theory as applied to passive dendritic trees and dendritic spines; chemical and electrical synapses and how to treat them from a computational point of view; nonlinear interactions of synaptic input in passive and active dendritic trees; the Hodgkin-Huxley model of action potential generation and propagation; phase space analysis; linking stochastic ionic channels to membrane-dependent currents; calcium and potassium currents and their role in information processing; the role of diffusion, buffering and binding of calcium, and other messenger systems in information processing and storage; short- and long-term models of synaptic plasticity; simplified models of single cells; stochastic aspects of neuronal firing; the nature of the neuronal code; and unconventional models of sub-cellular computation. Biophysics of Computation: Information Processing in Single Neurons serves as an ideal text for advanced undergraduate and graduate courses in cellular biophysics, computational neuroscience, and neural networks, and will appeal to students and professionals in neuroscience, electrical and computer engineering, and physics.
-
Front Matter
- Introduction
-
51
The Membrane Equation
-
252
Linear Cable Theory
-
493
Passive Dendritic Trees
-
854
Synaptic Input
-
1175
Synaptic Interactions In A Passive Dendritic Tree
-
1426
The Hodgkin-Huxley Model Of Action Potential Generation
-
1727
Phase Space Analysis Of Neuronal Excitability
-
1938
Ionic Channels
-
2129
Beyond Hodgkin And Huxley: Calcium And Calcium- Dependent Potassium Currents
-
23210
Linearizing Voltage-Dependent Currents
-
24811
Diffusion, Buffering, and Binding
-
28012
Dendritic Spines
-
30813
Synaptic Plasticity
-
33014
Simplified Models of Individual Neurons
-
35015
Stochastic Models of Single Cells
-
37416
Bursting Cells
-
38117
Input Resistance, Time Constants, and Spike Initiation
-
40218
Synaptic Input to a Passive Tree
-
42819
Voltage-Dependent Events in the Dendritic Tree
-
45220
Unconventional Computing
-
46921
Computing with Neurons: A Summary
-
End Matter
Sign in
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Purchase
Our books are available by subscription or purchase to libraries and institutions.
Purchasing informationMonth: | Total Views: |
---|---|
October 2022 | 1 |
October 2022 | 3 |
October 2022 | 3 |
October 2022 | 3 |
October 2022 | 7 |
October 2022 | 4 |
October 2022 | 1 |
October 2022 | 11 |
October 2022 | 3 |
October 2022 | 3 |
October 2022 | 4 |
October 2022 | 3 |
October 2022 | 3 |
October 2022 | 1 |
October 2022 | 3 |
October 2022 | 6 |
October 2022 | 3 |
October 2022 | 3 |
October 2022 | 5 |
October 2022 | 3 |
October 2022 | 3 |
October 2022 | 3 |
October 2022 | 3 |
October 2022 | 3 |
October 2022 | 1 |
October 2022 | 3 |
October 2022 | 3 |
October 2022 | 3 |
October 2022 | 3 |
October 2022 | 3 |
October 2022 | 15 |
October 2022 | 9 |
November 2022 | 1 |
November 2022 | 1 |
November 2022 | 1 |
November 2022 | 3 |
November 2022 | 21 |
November 2022 | 9 |
November 2022 | 2 |
November 2022 | 1 |
November 2022 | 2 |
November 2022 | 1 |
November 2022 | 1 |
November 2022 | 3 |
November 2022 | 5 |
November 2022 | 3 |
December 2022 | 1 |
December 2022 | 3 |
December 2022 | 3 |
December 2022 | 2 |
December 2022 | 3 |
December 2022 | 1 |
December 2022 | 1 |
December 2022 | 2 |
December 2022 | 1 |
January 2023 | 2 |
January 2023 | 1 |
January 2023 | 7 |
January 2023 | 2 |
January 2023 | 1 |
January 2023 | 2 |
January 2023 | 3 |
February 2023 | 5 |
February 2023 | 3 |
February 2023 | 5 |
February 2023 | 1 |
February 2023 | 2 |
February 2023 | 2 |
March 2023 | 2 |
March 2023 | 8 |
March 2023 | 3 |
March 2023 | 1 |
March 2023 | 2 |
March 2023 | 7 |
March 2023 | 1 |
March 2023 | 1 |
March 2023 | 1 |
March 2023 | 1 |
March 2023 | 1 |
April 2023 | 9 |
April 2023 | 10 |
April 2023 | 5 |
April 2023 | 9 |
April 2023 | 2 |
April 2023 | 9 |
April 2023 | 8 |
April 2023 | 9 |
April 2023 | 4 |
April 2023 | 6 |
April 2023 | 5 |
April 2023 | 2 |
April 2023 | 2 |
April 2023 | 2 |
April 2023 | 12 |
April 2023 | 4 |
April 2023 | 3 |
April 2023 | 2 |
April 2023 | 4 |
April 2023 | 2 |
April 2023 | 8 |
April 2023 | 4 |
April 2023 | 4 |
April 2023 | 4 |
April 2023 | 5 |
May 2023 | 2 |
May 2023 | 2 |
May 2023 | 14 |
May 2023 | 2 |
May 2023 | 8 |
May 2023 | 3 |
May 2023 | 3 |
May 2023 | 6 |
May 2023 | 2 |
May 2023 | 2 |
May 2023 | 2 |
May 2023 | 2 |
May 2023 | 2 |
May 2023 | 2 |
May 2023 | 2 |
May 2023 | 4 |
May 2023 | 2 |
May 2023 | 9 |
May 2023 | 3 |
May 2023 | 2 |
May 2023 | 2 |
May 2023 | 2 |
May 2023 | 2 |
May 2023 | 2 |
May 2023 | 2 |
May 2023 | 2 |
May 2023 | 2 |
May 2023 | 6 |
May 2023 | 2 |
May 2023 | 8 |
May 2023 | 2 |
May 2023 | 2 |
June 2023 | 2 |
June 2023 | 1 |
June 2023 | 2 |
June 2023 | 2 |
June 2023 | 2 |
June 2023 | 2 |
June 2023 | 2 |
June 2023 | 4 |
June 2023 | 3 |
June 2023 | 2 |
June 2023 | 2 |
June 2023 | 2 |
June 2023 | 2 |
June 2023 | 3 |
June 2023 | 2 |
June 2023 | 1 |
June 2023 | 2 |
June 2023 | 4 |
June 2023 | 2 |
June 2023 | 2 |
June 2023 | 1 |
June 2023 | 2 |
June 2023 | 2 |
June 2023 | 4 |
June 2023 | 2 |
June 2023 | 2 |
June 2023 | 2 |
June 2023 | 2 |
June 2023 | 2 |
June 2023 | 2 |
June 2023 | 1 |
June 2023 | 4 |
July 2023 | 1 |
July 2023 | 3 |
July 2023 | 4 |
July 2023 | 1 |
July 2023 | 2 |
July 2023 | 3 |
July 2023 | 1 |
July 2023 | 3 |
August 2023 | 1 |
August 2023 | 5 |
August 2023 | 1 |
August 2023 | 1 |
August 2023 | 3 |
August 2023 | 4 |
August 2023 | 1 |
August 2023 | 1 |
August 2023 | 10 |
August 2023 | 1 |
August 2023 | 3 |
August 2023 | 3 |
August 2023 | 5 |
August 2023 | 1 |
August 2023 | 2 |
August 2023 | 2 |
September 2023 | 3 |
September 2023 | 3 |
September 2023 | 5 |
September 2023 | 4 |
September 2023 | 2 |
September 2023 | 4 |
September 2023 | 1 |
September 2023 | 1 |
September 2023 | 1 |
September 2023 | 1 |
October 2023 | 23 |
October 2023 | 2 |
October 2023 | 1 |
October 2023 | 2 |
October 2023 | 3 |
October 2023 | 6 |
October 2023 | 2 |
October 2023 | 2 |
October 2023 | 2 |
October 2023 | 1 |
October 2023 | 2 |
October 2023 | 1 |
October 2023 | 3 |
October 2023 | 2 |
November 2023 | 8 |
November 2023 | 7 |
November 2023 | 1 |
November 2023 | 1 |
November 2023 | 2 |
November 2023 | 5 |
November 2023 | 2 |
November 2023 | 1 |
November 2023 | 6 |
December 2023 | 2 |
December 2023 | 2 |
December 2023 | 3 |
December 2023 | 1 |
January 2024 | 5 |
January 2024 | 2 |
January 2024 | 8 |
January 2024 | 2 |
January 2024 | 9 |
January 2024 | 4 |
January 2024 | 4 |
January 2024 | 3 |
January 2024 | 4 |
January 2024 | 5 |
January 2024 | 6 |
January 2024 | 2 |
January 2024 | 4 |
January 2024 | 6 |
January 2024 | 4 |
January 2024 | 4 |
January 2024 | 8 |
January 2024 | 8 |
January 2024 | 3 |
January 2024 | 4 |
January 2024 | 5 |
January 2024 | 12 |
January 2024 | 5 |
January 2024 | 3 |
January 2024 | 3 |
January 2024 | 4 |
January 2024 | 4 |
January 2024 | 4 |
January 2024 | 4 |
January 2024 | 2 |
January 2024 | 4 |
January 2024 | 6 |
February 2024 | 4 |
February 2024 | 3 |
February 2024 | 3 |
February 2024 | 2 |
February 2024 | 1 |
February 2024 | 2 |
February 2024 | 1 |
February 2024 | 5 |
February 2024 | 1 |
February 2024 | 1 |
March 2024 | 1 |
March 2024 | 7 |
March 2024 | 1 |
March 2024 | 1 |
March 2024 | 3 |
March 2024 | 1 |
March 2024 | 3 |
March 2024 | 2 |
March 2024 | 3 |
March 2024 | 10 |
March 2024 | 1 |
March 2024 | 1 |
March 2024 | 1 |
March 2024 | 2 |
April 2024 | 1 |
April 2024 | 1 |
April 2024 | 16 |
April 2024 | 6 |
April 2024 | 4 |
April 2024 | 2 |
April 2024 | 4 |
April 2024 | 2 |
April 2024 | 1 |
April 2024 | 3 |
April 2024 | 3 |
April 2024 | 2 |
April 2024 | 3 |
April 2024 | 9 |
April 2024 | 1 |
April 2024 | 1 |
April 2024 | 2 |
April 2024 | 1 |
April 2024 | 1 |
April 2024 | 1 |
May 2024 | 3 |
May 2024 | 1 |
May 2024 | 2 |
May 2024 | 2 |
May 2024 | 1 |
May 2024 | 2 |
May 2024 | 1 |
May 2024 | 4 |
May 2024 | 4 |
May 2024 | 1 |
May 2024 | 3 |
May 2024 | 1 |
May 2024 | 4 |
May 2024 | 1 |
June 2024 | 9 |
June 2024 | 1 |
June 2024 | 3 |
June 2024 | 5 |
June 2024 | 9 |
June 2024 | 3 |
June 2024 | 7 |
June 2024 | 5 |
June 2024 | 3 |
June 2024 | 3 |
June 2024 | 4 |
June 2024 | 4 |
June 2024 | 4 |
June 2024 | 4 |
June 2024 | 3 |
June 2024 | 2 |
June 2024 | 5 |
June 2024 | 5 |
June 2024 | 3 |
June 2024 | 3 |
June 2024 | 4 |
June 2024 | 4 |
June 2024 | 3 |
June 2024 | 1 |
June 2024 | 1 |
June 2024 | 2 |
June 2024 | 8 |
June 2024 | 2 |
June 2024 | 4 |
June 2024 | 1 |
July 2024 | 10 |
July 2024 | 4 |
July 2024 | 1 |
July 2024 | 1 |
July 2024 | 3 |
July 2024 | 1 |
July 2024 | 2 |
July 2024 | 1 |
July 2024 | 4 |
July 2024 | 1 |
July 2024 | 2 |
August 2024 | 10 |
August 2024 | 1 |
August 2024 | 2 |
August 2024 | 4 |
August 2024 | 2 |
August 2024 | 6 |
August 2024 | 1 |
August 2024 | 1 |
September 2024 | 5 |
September 2024 | 1 |
September 2024 | 6 |
September 2024 | 3 |
September 2024 | 10 |
September 2024 | 1 |
September 2024 | 2 |
September 2024 | 3 |
September 2024 | 1 |
October 2024 | 5 |
October 2024 | 15 |
October 2024 | 4 |
October 2024 | 10 |
October 2024 | 4 |
October 2024 | 3 |
October 2024 | 6 |
October 2024 | 5 |
October 2024 | 2 |
October 2024 | 1 |
October 2024 | 2 |
October 2024 | 3 |
October 2024 | 6 |
October 2024 | 8 |
October 2024 | 2 |
October 2024 | 2 |
October 2024 | 4 |
October 2024 | 2 |
October 2024 | 4 |
October 2024 | 5 |
October 2024 | 4 |
October 2024 | 4 |
October 2024 | 5 |
October 2024 | 2 |
October 2024 | 7 |
October 2024 | 11 |
October 2024 | 2 |
November 2024 | 12 |
November 2024 | 6 |
November 2024 | 2 |
November 2024 | 1 |
November 2024 | 1 |
November 2024 | 1 |
November 2024 | 2 |
November 2024 | 2 |
November 2024 | 5 |
November 2024 | 2 |
December 2024 | 3 |
December 2024 | 1 |
December 2024 | 7 |
December 2024 | 6 |
December 2024 | 5 |
December 2024 | 8 |
December 2024 | 3 |
December 2024 | 3 |
December 2024 | 4 |
December 2024 | 4 |
December 2024 | 4 |
December 2024 | 5 |
December 2024 | 3 |
December 2024 | 3 |
December 2024 | 1 |
December 2024 | 3 |
December 2024 | 3 |
December 2024 | 6 |
December 2024 | 7 |
December 2024 | 8 |
December 2024 | 3 |
December 2024 | 3 |
December 2024 | 3 |
December 2024 | 9 |
December 2024 | 3 |
December 2024 | 7 |
December 2024 | 4 |
December 2024 | 5 |
December 2024 | 7 |
December 2024 | 3 |
December 2024 | 8 |
December 2024 | 6 |
January 2025 | 2 |
January 2025 | 2 |
January 2025 | 5 |
January 2025 | 1 |
January 2025 | 5 |
January 2025 | 3 |
January 2025 | 2 |
January 2025 | 2 |
January 2025 | 3 |
January 2025 | 2 |
January 2025 | 4 |
January 2025 | 8 |
January 2025 | 4 |
January 2025 | 6 |
January 2025 | 1 |
January 2025 | 2 |
January 2025 | 2 |
January 2025 | 2 |
January 2025 | 3 |
January 2025 | 5 |
January 2025 | 5 |
January 2025 | 2 |
January 2025 | 2 |
January 2025 | 2 |
January 2025 | 2 |
January 2025 | 10 |
January 2025 | 5 |
January 2025 | 2 |
January 2025 | 7 |
January 2025 | 2 |
January 2025 | 3 |
January 2025 | 3 |
February 2025 | 4 |
February 2025 | 3 |
February 2025 | 10 |
February 2025 | 2 |
February 2025 | 4 |
February 2025 | 11 |
February 2025 | 4 |
February 2025 | 5 |
February 2025 | 6 |
February 2025 | 6 |
February 2025 | 4 |
February 2025 | 4 |
February 2025 | 7 |
February 2025 | 5 |
February 2025 | 2 |
February 2025 | 14 |
February 2025 | 5 |
February 2025 | 6 |
February 2025 | 4 |
February 2025 | 7 |
February 2025 | 4 |
February 2025 | 3 |
February 2025 | 4 |
February 2025 | 8 |
February 2025 | 4 |
February 2025 | 2 |
February 2025 | 8 |
February 2025 | 2 |
February 2025 | 4 |
February 2025 | 4 |
February 2025 | 4 |
February 2025 | 4 |
March 2025 | 5 |
March 2025 | 1 |
March 2025 | 2 |
March 2025 | 2 |
March 2025 | 1 |
March 2025 | 1 |
March 2025 | 1 |
March 2025 | 1 |
March 2025 | 1 |
March 2025 | 12 |
March 2025 | 2 |
March 2025 | 2 |
March 2025 | 1 |
March 2025 | 1 |
March 2025 | 6 |
April 2025 | 3 |
April 2025 | 6 |
April 2025 | 5 |
April 2025 | 1 |
April 2025 | 8 |
April 2025 | 4 |
April 2025 | 2 |
April 2025 | 4 |
April 2025 | 4 |
April 2025 | 5 |
April 2025 | 4 |
April 2025 | 3 |
April 2025 | 3 |
April 2025 | 4 |
April 2025 | 3 |
April 2025 | 2 |
April 2025 | 1 |
April 2025 | 8 |
April 2025 | 4 |
April 2025 | 5 |
April 2025 | 2 |
April 2025 | 9 |
April 2025 | 4 |
April 2025 | 3 |
April 2025 | 4 |
April 2025 | 5 |
April 2025 | 3 |
April 2025 | 5 |
April 2025 | 4 |
April 2025 | 2 |
April 2025 | 4 |
April 2025 | 3 |
May 2025 | 1 |
May 2025 | 2 |
May 2025 | 1 |
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.