A Life Course Approach to Mental Disorders
A Life Course Approach to Mental Disorders
Associate Professor
Gelman Professor and Chair
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Abstract
A life course approach to mental disorders is concerned with the interplay of social and biological factors in the production of mental illness over the life span – from the postnatal period to old age. Life course epidemiology considers this interplay in the population-based context with specific focus on its relevance to public health. The ageing into adulthood of numerous birth cohorts, especially over the past twenty years, has provided increasing evidence that mental disorders previously perceived to emerge in adulthood may have their origins early in life. Although the ageing of birth cohorts has been accompanied by an explosion in research in the life course epidemiology of mental disorders, there currently exists no single source that has brought this research together with the goal of forging a consensus on the current science and pointing the way to next steps for the field. This book therefore aims to be first comprehensive articulation of a life course perspective on mental disorders. Researchers are brought together from disparate disciplines—epidemiology, developmental psychopathology, psychiatric genetics, sociology, developmental cognitive neuroscience, and epigenetics—to review the methods and synthesize the existing knowledge about the life course epidemiology of mental disorders in populations. This book also discusses the mechanisms that drive the production of mental disorders over the life course and of emerging areas of research in the field. The goal is to bring together the state of the science of life course epidemiology to inform training, research, practice, and policy with regard to mental disorders.
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Front Matter
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Part 1 Introduction
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Part 2 Methods in life course approaches
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2
Study designs: traditional and novel approaches to advance life course research
Stephen L. Buka andMary E. Lacy
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3
Measurement issues in epidemiology of psychiatric disorders
Patricia Cohen
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4
Analytic considerations in a life course perspective
Leah Li
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5
Age, birth cohort, and period effects in psychiatric disorders in the USA
Katherine Keyes andCharley Liu
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2
Study designs: traditional and novel approaches to advance life course research
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Part 3 Life course approach to specific mental disorders
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6
Schizophrenia and related psychosis
Golam M. Khandaker and others
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7
Bipolar disorder
Leslie Hulvershorn andJohn Nurnberger, Jr.
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8
Applying a life course perspective to depression
Sasha Rudenstine
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9
Life course epidemiology of anxiety disorders
Renee D. Goodwin and others
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10
Epidemiology of post-traumatic stress disorder
Nicole R. Nugent and others
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11
Life course approach to substance use
Jennifer Ahern andHannah H. Leslie
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12
The life course perspective: a framework for autism research
Michaeline Bresnahan and others
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13
Life course epidemiology of eating disorders
Karen S. Mitchell andCynthia M. Bulik
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14
Attention deficit/hyperactivity disorder over the life course
Jessica Agnew-Blais andLarry J. Seidman
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15
Conduct disorder across the life course
Sara R. Jaffee andCandice L. Odgers
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16
Borderline, schizotypal, avoidant, obsessive–compulsive, and other personality disorders
Andrew E. Skodol
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6
Schizophrenia and related psychosis
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Part 4 Understanding mechanisms
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17
Cognitive function over the life course
Marcus Richards
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18
Life course approaches to the genetic epidemiology of mental illness
Elise B. Robinson and others
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19
Impact of early environmental exposures on mental disorders across the life course
Pam Factor-Litvak
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20
Role of the social environmental over the life course in the aetiology of psychiatric disorders
Stephen E. Gilman andJessica R. Marden
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21
Social context and mental health over the life course
Arijit Nandi andLauren Welsh
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22
Epigenetic influences on mental illness over the life course
Monica Uddin andLevent Sipahi
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23
Adverse childhood experiences and brain development: neurobiological mechanisms linking the social environment to psychiatric disorders
Katie A. McLaughlin and others
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24
Social–biological interplay over the life course
Kelly Skelton and others
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17
Cognitive function over the life course
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Part 5 New directions in the life course epidemiology of mental illness
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Part 6 Conclusions
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End Matter
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