Imaging the Aging Brain
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Introduction Introduction
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Methodological Considerations Methodological Considerations
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Impaired Cerebral Activity Pattern Observed in Alzheimer’s Disease Impaired Cerebral Activity Pattern Observed in Alzheimer’s Disease
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Differentiating AD and Depression Differentiating AD and Depression
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Can Functional Imaging Distinguish AD from Vascular Dementia? Can Functional Imaging Distinguish AD from Vascular Dementia?
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AD and Hydrocephalus AD and Hydrocephalus
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AD Versus Lewy Body Dementia AD Versus Lewy Body Dementia
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Differential Diagnosis of Parkinsonian Syndromes with Dementia Differential Diagnosis of Parkinsonian Syndromes with Dementia
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Metabolic Pattern in FTD versus AD Metabolic Pattern in FTD versus AD
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Semantic Dementia, Nonfluent Primary Progressive Aphasia and AD Semantic Dementia, Nonfluent Primary Progressive Aphasia and AD
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Creutzfeldt Jakob Disease Creutzfeldt Jakob Disease
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Conclusions Conclusions
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References References
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15 15 Differential Diagnosis of Dementia Using Functional Neuroimaging
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Published:22 October 2009
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Abstract
Functional neuroimaging in neurodegenerative dementias provides 3D representations of brain activity that are relatively characteristic of the underlying phenotypic distribution of cerebral lesions. They are not specific for a given brain pathology and the heterogeneity of brain diseases must always be considered. However, when methodologies are optimized, the values for sensitivity, specificity, and early diagnostic accuracy approach 80%. A lot of studies have shown that Alzheimer's disease can be distinguished from depression, vascular dementia or frontotemporal dementia, and Lewy body dementia when two techniques are used. General recommendations are to rely on multiple key regions and to combine different neuroimaging techniques to make a differential diagnosis among dementias.
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