
Lesley Rees
et al.
Published online:
01 May 2012
Published in print:
01 August 2012
Online ISBN:
9780191730634
Print ISBN:
9780199601370
Contents
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Disorders of renal salt handling: basic principles Disorders of renal salt handling: basic principles
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Disorders of renal salt handling: proximal tubule Disorders of renal salt handling: proximal tubule
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Presentation Presentation
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Investigations Investigations
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Treatment Treatment
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Acquired causes of Fanconi syndrome Acquired causes of Fanconi syndrome
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Drugs/toxins Drugs/toxins
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Renal causes Renal causes
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Disorders of renal salt handling: thick ascending limb Disorders of renal salt handling: thick ascending limb
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Clinical features Clinical features
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Key symptoms Key symptoms
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Additional symptoms Additional symptoms
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Investigation Investigation
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Diagnosis Diagnosis
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Treatment Treatment
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Disorders of renal salt handling: distal convoluted tubule Disorders of renal salt handling: distal convoluted tubule
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Clinical features Clinical features
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Gitelman syndrome Gitelman syndrome
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EAST syndrome EAST syndrome
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Treatment Treatment
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Gitelman syndrome Gitelman syndrome
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Pseudohypoaldosteronism type 2 Pseudohypoaldosteronism type 2
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Disorders of renal salt handling: collecting duct Disorders of renal salt handling: collecting duct
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Diagnosis Diagnosis
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Treatment Treatment
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Pseudohypoaldosteronism type 1 Pseudohypoaldosteronism type 1
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Liddle syndrome and AME Liddle syndrome and AME
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GRA and CAH GRA and CAH
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Disorders of renal water handling Disorders of renal water handling
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Basic principles Basic principles
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Nephrogenic diabetes insipidus Nephrogenic diabetes insipidus
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Genetics of nephrogenic diabetes insipidus Genetics of nephrogenic diabetes insipidus
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Clinical features (primary, X-linked genetic nephrogenic diabetes insipidus) Clinical features (primary, X-linked genetic nephrogenic diabetes insipidus)
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Investigations Investigations
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Water deprivation test and DDAVP® test Water deprivation test and DDAVP® test
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Management of primary (genetic) nephrogenic diabetes insipidus Management of primary (genetic) nephrogenic diabetes insipidus
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Diet Diet
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Drug therapy Drug therapy
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Management of NDI during intercurrent illness, and peri-operatively Management of NDI during intercurrent illness, and peri-operatively
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Acquired (secondary) nephrogenic diabetes insipidus Acquired (secondary) nephrogenic diabetes insipidus
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Nephrogenic syndrome of inappropriate antidiuresis Nephrogenic syndrome of inappropriate antidiuresis
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Disorders of renal magnesium handling Disorders of renal magnesium handling
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Basic principles Basic principles
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Disorders in TAL are associated with hypercalciuria Disorders in TAL are associated with hypercalciuria
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Disorders in the distal convoluted tubule affecting magnesium reabsorption only are associated with normocalciuria Disorders in the distal convoluted tubule affecting magnesium reabsorption only are associated with normocalciuria
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Disorders in the distal convoluted tubule primarily affecting sodium reabsorption are associated with hypocalciuria Disorders in the distal convoluted tubule primarily affecting sodium reabsorption are associated with hypocalciuria
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Investigations and treatment Investigations and treatment
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Rickets Rickets
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General principles General principles
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Tubulointerstitial nephritis Tubulointerstitial nephritis
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Basic principles Basic principles
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Clinical features of acute tubulointerstitial nephritis Clinical features of acute tubulointerstitial nephritis
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Causes of acute tubulointerstitial nephritis Causes of acute tubulointerstitial nephritis
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Causes of chronic tubulointerstitial nephritis Causes of chronic tubulointerstitial nephritis
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Laboratory features Laboratory features
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Blood Blood
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Urine Urine
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Renal ultrasound Renal ultrasound
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Ophthalmology review Ophthalmology review
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Renal biopsy Renal biopsy
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Treatment of tubulointerstitial nephritis Treatment of tubulointerstitial nephritis
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Prognosis of tubulointerstitial nephritis Prognosis of tubulointerstitial nephritis
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Further reading Further reading
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Cite
Rees, Lesley, and others, 'Tubular disease', Paediatric Nephrology, 2 edn, Oxford Specialist Handbooks (Oxford , 2012; online edn, Oxford Academic, 1 May 2012), https://doi.org/10.1093/med/9780199601370.003.0066, accessed 8 May 2025.
Extract
Disorders of renal salt handling: basic principles
Clinical and molecular characteristics of renal salt handling disorders
...
Disorders of renal salt handling: proximal tubule
Genetic causes of Fanconi syndrome
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Presentation
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Investigations
Typical constellation of biochemistries in proximal tubular dysfunction
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Treatment
...
Acquired causes of Fanconi syndrome
Drugs/toxins
...
Renal causes
...
Fig. 7.2 represents an epithelial cell in the proximal tubule. Na is reabsorbed either in exchange with substances that need to be secreted (such as protons via the Na–H exchanger (NHE3)) or in co-transport with substances that need to be reabsorbed (such as P or glucose). The epithelial cells in the proximal tubule (PT) all express the water channel AQP1, so that solutes are reabsorbed isotonically with water.
...
Disorders of renal salt handling: thick ascending limb
...
Clinical features
Key symptoms
...
Additional symptoms
...
Investigation
...
Diagnosis
...
Treatment
Collection:
Oxford Medicine Online
Disclaimer
Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct.
Readers must therefore always …
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Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct.
Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets
provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or
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