
Contents
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Introduction Introduction
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The Genome The Genome
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The Chromosome The Chromosome
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Epigenetics Epigenetics
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Non-coding RNA (ncRNA) Non-coding RNA (ncRNA)
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Implications for Migraine Research Implications for Migraine Research
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Migraine Genetics Migraine Genetics
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Familial Hemiplegic Migraine: A Monogenic Migraine Subtype Familial Hemiplegic Migraine: A Monogenic Migraine Subtype
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Genes for Common Migraine Subtypes Genes for Common Migraine Subtypes
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Genome-Wide Association Studies Genome-Wide Association Studies
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Migraine Genome-Wide Association Studies Migraine Genome-Wide Association Studies
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Other Migraine Genes Other Migraine Genes
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Migraine and Genetic Vasculopathies Migraine and Genetic Vasculopathies
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Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
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Retinal Vasculopathy with Cerebral Leukodystrophy (RVCL) Retinal Vasculopathy with Cerebral Leukodystrophy (RVCL)
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Hereditary Systemic Angiopathy Hereditary Systemic Angiopathy
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COL4A1-Related Disorder COL4A1-Related Disorder
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References References
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Cite
Abstract
Migraine is a complex neurological disorder with a strong genetic basis. Familial hemiplegic migraine is a classic monogenic subtype of which there are three well defined genes implicated. There are also a number of monogenic disorders where migraine is a prominent clinical feature. Migraine with and without aura are considered to be polygenic. Genome-wide association studies have identified a several genes involved in neuronal and vascular mechanisms that are associated with migraine and have the potential to advance the understanding of migraine pathogenesis as well as identify potentially new therapeutic targets. In this chapter, the authors provide insight into how current knowledge of migraine genetics facilitates an understand on the neurobiology of migraine.
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