
Contents
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Introduction Introduction
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Immunology Basics Immunology Basics
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Immune Responses in Ovarian Cancer Patients Immune Responses in Ovarian Cancer Patients
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Roadblocks to Immunity in Ovarian Cancer Roadblocks to Immunity in Ovarian Cancer
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Loss or Downregulation of Tumor Antigen Loss or Downregulation of Tumor Antigen
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Production of Immune Suppressive Cytokines Production of Immune Suppressive Cytokines
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Expression of Immune Suppressive Molecules Expression of Immune Suppressive Molecules
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Recruitment of Suppressive Immune Cells Recruitment of Suppressive Immune Cells
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Physical Barriers to Immune Responses Physical Barriers to Immune Responses
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Immunotherapy as a Therapeutic Approach in Metastatic Ovarian Cancer Immunotherapy as a Therapeutic Approach in Metastatic Ovarian Cancer
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Antibodies Antibodies
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Immune Checkpoint Inhibitors Immune Checkpoint Inhibitors
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Adoptive Cell Therapy Adoptive Cell Therapy
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DC-Based Vaccines DC-Based Vaccines
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Other Immunologically Important Approaches Other Immunologically Important Approaches
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Summary and Future Perspectives Summary and Future Perspectives
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Acknowledgments Acknowledgments
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References References
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12. Unique Challenges Facing Immunotherapy of Metastatic Ovarian Cancer
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Published:August 2018
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Abstract
The immune system serves as an integral checkpoint to developing malignancies. However, when cancer ultimately becomes detectable, this implicates an inherent failure of effective immune control. One constant theme in cancer biology has been the ability of these “diseases,” in particular, ovarian cancer, to compromise immune-mediated mechanisms of neoplastic control. These empirical observations have subsequently laid the scientific foundation to investigate ways in which the immune system can be reengaged as a powerful therapeutic weapon, singly or in combination with other modalities. This field has been coined “cancer immunotherapy” and, importantly, strong progress has been made to date to justify its feasibility and potential merit. This chapter focuses on the fundamental immunologic principles that have guided the development of the cancer immunotherapy concept, as well as details both the successes and the limitations of cancer immunotherapy in patients with metastatic ovarian cancer.
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