
Contents
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18.1 Introduction 18.1 Introduction
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18.2 Quality assurance for clinical fMRI 18.2 Quality assurance for clinical fMRI
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18.2.1 Personnel 18.2.1 Personnel
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18.2.2 Patient preparation 18.2.2 Patient preparation
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18.2.3 Patient safety 18.2.3 Patient safety
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18.2.4 Paradigms 18.2.4 Paradigms
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18.2.5 Scanner 18.2.5 Scanner
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18.2.6 Control system 18.2.6 Control system
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18.2.7 Data analysis 18.2.7 Data analysis
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18.2.8 Data presentation 18.2.8 Data presentation
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18.3 Mechanism of BOLD fMRI and its assumptions in clinical applications 18.3 Mechanism of BOLD fMRI and its assumptions in clinical applications
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18.3.1 Spatial resolution 18.3.1 Spatial resolution
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18.3.2 Haemodynamic coupling in disease 18.3.2 Haemodynamic coupling in disease
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18.4 Clinical cases demonstrating fMRI applications 18.4 Clinical cases demonstrating fMRI applications
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18.4.1 Presurgical planning 18.4.1 Presurgical planning
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Arteriovenous malformations Arteriovenous malformations
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Brain tumors Brain tumors
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18.4.2 Diagnosis 18.4.2 Diagnosis
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Alzheimer's disease Alzheimer's disease
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18.4.3 Rehabilitation therapy 18.4.3 Rehabilitation therapy
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Stroke Stroke
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18.5 Conclusion 18.5 Conclusion
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References References
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18 Clinical applications of mapping neurocognitive processes in the human brain with functional MRI
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Published:November 2001
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Abstract
A critical issue in functional magnetic resonance imaging (fMRI) is to ensure that the subject is performing the required task. This can be important particularly in clinical studies. Clinical applications of fMRI conducted thus far can be summarized in three general areas. This chapter deals with aspects of these applications along with special problems associated with patient studies, and presents strategies that serve to meet these challenges. Quality control of the imaging environment, patient preparation and selection, as well as appropriately calibrated paradigms, are also discussed. The chapter reviews quality assurance and considers several aspects of the fMRI examination to ensure this level of success, concluding that fMRI has now become an exciting window onto brain function in many patient populations currently thought to be inappropriate for imaging.
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