Abstract

A number of hormonal conditions, notably disorders of thyroid function and pituitary dependent Cushing's disease, are associated with the development of a psychotic illness. Abnormalities of anterior and posterior pituitary hormones are seen in psychotic illness—dysregulation of thyroid and adrenal function is relatively common. However, the interpretation of these observations is problematical and no one mechanism has been implicated. Hypothalamic peptides are crucial in hormonal regulation but also have extensive CNS distributions and this is likely to be the focus of future research.

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