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Hugo P. Dilhuydy, Daniel McNamara, Raymond J. Lemieux, Yves Martel, Jacques A. de Guise, Three-dimensional imaging of dual isotope data-sets in a case of acute myocardial infarction, British Journal of Radiology, Volume 65, Issue 771, 1 March 1992, Pages 273–278, https://doi.org/10.1259/0007-1285-65-771-273
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A patient with acute myocardial infarction was injected with indium 111 (111In)-antimyosin Fab. He then under-went planar imaging before receiving an additional dose of thallium 201 (2O1T1) so as to perform a dual isotope single photon emission computed tomography (SPECT) acquisition. Planar images showed vague myocardial uptake of antimyosin antibody. With tomographic slices, a more defined area of antimyosin uptake was seen but still with a low 111In signal-to-noise ratio. This area corresponded to a 2O1T1 defect. Two three-dimensional (3D) rendering methods showed a well matched 2O1T1 3D defect and 111In 3D hot spot and seemed to facilitate the localization of the infarct as well as the evaluation of its importance relative to the remaining viable tissue. This case study illustrates a situation where 3D imaging of dual isotope data-sets could be useful for direct visualization and localization of myocardial infarction.
A 61-year-old white male with a past history of occasional chest pain was admitted to the ICU for prolonged chest pain. He had multiple risk factors for coronary disease such as smoking (up to 40 cigarettes per day), essential hypertension, diabetes and a family history of coronary artery disease. Laboratory analysis showed elevated plasma enzyme levels of total creatine kinase (CK) (1289 U/l) and the electro-cardiogram showed an infarct in the anterior wall and a possible old inferior wall infarction (see Fig. 1). Five days after his admission coronary angiography revealed severe three-vessel disease.
