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Shrieve and Denekamp (1985) conclude that misonidazole (MISO) is not more efficient in GSH-depleted cells than in untreated cells. They point out that although their experimental studies on the radiosensitisation of GSH-depleted hypoxic cells by oxygen or MISO (Shrieve et al, 1984) are similar to those of others in the literature, their conclusion is the opposite of that reached by others, and arises as a result of a different method of analysing the data compared to that of previous authors. Their, method is to use the hypoxic control line (survival curve) of the GSH-depleted cells as the starting point for determing sensitising enhancement ratio (SER), rather than the hypoxic control line of untreated (i.e., GSH-proficient) cells as used by others. They show that when this is done, the increase in MISO efficiency of 5–30 claimed by previous workers is greatly diminished to factors of less than 3, and for most studies, including their own, is indistinguishable from 1.0. In other words, they conclude that the hypoxic sensitisation produced by GSH depletion and by MISO are essentially additive or non-interactive.

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