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L.C. Strazzulla, L. Avila, K. Lo Sicco, J. Shapiro, Image Gallery: Treatment of refractory alopecia universalis with oral tofacitinib citrate and adjunct intralesional triamcinolone injections, British Journal of Dermatology, Volume 176, Issue 6, 1 June 2017, Page e125, https://doi.org/10.1111/bjd.15483
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Funding sources: none.
Conflicts of interest: none declared.
Dear Editor, A young man with alopecia universalis (top) refractory to methotrexate was started on tofacitinib (a Janus kinase inhibitor), which may promote hair regrowth in severe alopecia areata (AA).1 This was combined with monthly injections of corticosteroids into the eyebrows and scalp – a common therapy for AA – which, like Janus kinase inhibitors, reduces inflammation around hair follicles.2 After 10 months of tofacitinib treatment combined with triamcinolone injections (2·5 mg mL−1) into the eyebrows from the start of treatment, and into the scalp starting after 7 months of treatment, the patient achieved near complete regrowth (bottom). His nails remained dystrophic with mild improvement. No adverse effects were observed.