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N. Dinani, E. Topham, E. Derrick, L. Atkinson, Ablative fractional laser assisted photodynamic therapy for the treatment of actinic cheilitis, British Journal of Dermatology, Volume 173, Issue 1, 1 July 2015, Page 15, https://doi.org/10.1111/bjd.13911
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ORIGINAL ARTICLE, p 184
Actinic cheilitis (AC) is a potentially malignant disorder of the lips caused by chronic or excessive solar radiation.1 2 As such, early treatment of AC is important. Current recommended treatment of AC includes topical 5‐fluorouracil, diclofenac or imiquimod, cryosurgery, curettage, scalpel vermilionectomy or photodynamic therapy (PDT).3 The lip is a cosmetically sensitive area and with our ageing population the prevalence of AC can be expected to rise. Therefore, studies into alternative, more effective treatment options are paramount.
In this issue of the BJD, Choi et al.4 report the results of the first prospective, randomized study comparing efficacy, recurrence rate, cosmetic outcome and safety between erbium:yttrium–aluminium–garnet ablative fractional laser‐assisted methyl aminolaevulinate‐PDT (Er:YAG AFL MAL‐PDT) and standard MAL‐PDT in 33 Korean patients with biopsy‐proven AC.4 Patients were randomized to receive one session of Er:YAG AFL MAL‐PDT or two sessions of MAL‐PDT. Lesion response, recurrence rate, cosmetic outcome and adverse events were compared. In the intent‐to‐treat population Er:YAG AFL MAL‐PDT was significantly more effective with a 12‐month response rate of 79% compared with 26% in the MAL‐PDT arm (P =0·012). No significant difference in cosmetic outcome or safety was observed.