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R. Alghamdi, C. Bejar, M. Steff, L. Deschamps, E. Marinho, B. Crickx, V. Descamps, Intravenous immunoglobulins as a treatment of interstitial granulomatous dermatitis with arthritis, British Journal of Dermatology, Volume 167, Issue 1, 1 July 2012, Pages 218–220, https://doi.org/10.1111/j.1365-2133.2012.10854.x
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Funding sources: none.
Conflicts of interest: none declared.
Madam, Interstitial granulomatous dermatitis with arthritis (IGDA) is an uncommon idiopathic dermatosis with various cutaneous expressions, including subcutaneous linear cords or bands, plaques and papules.1 The diagnosis of IGDA depends on histological confirmation with, in particular, the presence of infiltrate in the reticular dermis, a predominance of interstitial and palisading histiocytes and a few areas of degenerative collagen bundles associated with a variable number of polynuclear neutrophils and eosinophils.2 We report a case of IGDA with a dramatic improvement after treatment with intravenous immunoglobulins (IVIG).
An 81‐year‐old woman presented with progressive pruritic inflammatory erythematosus plaques on the face, trunk and limbs which she had had for 5 years; there was a sharp demarcation of the plaques with the healthy skin. She also complained of joint pain for several years. Prior examinations, which included a skin biopsy, had shown histological signs of an interstitial pattern of granuloma annulae, monoclonal gammopathy of unknown significance (MGUS) and positive anticyclic citrullinated peptide antibody. Various treatments did not improve the cutaneous lesions (topical corticosteroids, tacrolimus ointment, vitamin therapy, hydroxychloroquine and phototherapy).
