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G. Sethuraman, B.K. Khaitan, S.S. Dash, K. Chandramohan, V.K. Sharma, M. Kabra, K.K. Verma, R. Goswami, S. Thulkar, Ichthyosiform erythroderma with rickets: report of five cases, British Journal of Dermatology, Volume 158, Issue 3, 1 March 2008, Pages 603–606, https://doi.org/10.1111/j.1365-2133.2007.08355.x
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Summary
We describe five children with ichthyosis and rickets. The association of ichthyosis and rickets is very rare. Four children had lamellar ichthyosis and one child had nonbullous ichthyosiform erythroderma/psoriasis with atopy. All had biochemical and radiological evidence of rickets. Three had clinically evident rickets, of whom two had very severe skeletal deformities. Such a severe skeletal involvement due to rickets in association with ichthyosis is exceptionally rare. We suggest that children with severe ichthyosis, in particular those with pigmented skin, need to be evaluated for rickets, especially in developing countries where there is a background prevalence of vitamin D deficiency.