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F.B. Müller, W. Groth, Annular elastolytic giant cell granuloma: a prodromal stage of mid‐dermal elastolysis?, British Journal of Dermatology, Volume 156, Issue 6, 1 June 2007, Pages 1377–1378, https://doi.org/10.1111/j.1365-2133.2007.07902.x
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Conflicts of interest: none declared.
Sir, Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous dermatosis characterized by annular plaques with central atrophy and raised erythematous margins and usually located on the facial and neck areas of middle‐aged women. However, some cases of AEGCG involve body regions not exposed to ultraviolet (UV) radiation and generalized forms have been described.1, 2
Here we report a case of AEGCG resolving with clinical and histological features of generalized mid‐dermal elastolysis (MDE) suggesting that AEGCG might represent an inflammatory variant or prodromal stage of MDE.
A 36‐year‐old woman presented with a 3‐month history of an extensive, slightly pruritic, skin eruption involving extremities, abdomen, lower back, axillary regions and décolleté and to a lesser extent both cheeks, covering about 50% of the skin surface. In the past, the patient had suffered from prurigo‐type atopic dermatitis and recurring dyshidrotic palmar eczema. Apart from oral contraception no medication was taken. The patient smoked about 10 cigarettes a day. Except for a raised serum IgE of 648 kU L−1 (normal < 100) and polyvalent type‐I allergies in prick testing no abnormal laboratory findings were found.
