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S. Morizane, T. Yamamoto, Y. Hisamatsu, K. Tsuji, T. Oono, T. Hashimoto, K. Iwatsuki, Pemphigus vegetans with IgG and IgA antidesmoglein 3 antibodies, British Journal of Dermatology, Volume 153, Issue 6, 1 December 2005, Pages 1236–1237, https://doi.org/10.1111/j.1365-2133.2005.06956.x
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Conflicts of interest: none declared.
Sir, Pemphigus vegetans is an uncommon variant of pemphigus that is characterized by vegetating erosions on the intertriginous area. Direct immunofluorescence (DIF) reveals IgG deposition on keratinocyte cell surfaces in the epidermis in all cases, usually associated with C3 deposition. A few case reports of pemphigus vegetans demonstrated IgA deposition on keratinocyte cell surfaces, although the nature of the IgA‐class antibodies remains to be determined.1 We describe a patient with pemphigus vegetans who had both IgG and IgA antidesmoglein (Dsg) 3 antibodies.
A 67‐year‐old Japanese man visited our hospital in August 2003 because of a 2‐month history of pustules and erosions appearing on his face, axillae and groins. The skin lesions extended to the abdomen, buttocks and scalp. He had had a gastric ulcer and cerebral infarction at the age of 58 and 61 years, respectively, and he was treated with an antihypertensive drug. Cutaneous examination revealed pustules and erosions on the verrucous plaques in the above‐mentioned areas (Fig. 1). Aphthae and white plaques were seen in the oral mucosa and soft palate.
