-
Views
-
Cite
Cite
H.S. Beltraminelli, M. Lerch, A. Arnold, A.J. Bircher, P. Haeusermann, Acute generalized exanthematous pustulosis induced by the antifungal terbinafine: case report and review of the literature, British Journal of Dermatology, Volume 152, Issue 4, 1 April 2005, Pages 780–783, https://doi.org/10.1111/j.1365-2133.2005.06393.x
- Share Icon Share
Summary
Cutaneous drug reactions occur with a frequency of 1–8% and can be higher for certain classes of drugs. They can range from mild morbilliform eruptions to more severe forms such as drug‐hypersensitivity syndrome, toxic epidermal necrolysis or anaphylaxis. Acute generalized exanthematous pustulosis (AGEP) is considered to be a clinical reaction pattern, which is induced in over 90% of the cases by systemic drugs. It is a rare presentation of an adverse drug reaction most frequently triggered by anti‐infectious drugs. A high proportion of these cases have been attributed to aminopenicillins and macrolides. We report a terbinafine‐induced AGEP in a 68‐year‐old male confirmed by lymphocyte stimulation in vitro, and review the published cases induced by antimycotic drugs with special emphasis on terbinafine‐triggered cases.