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A. Ohshima, Y. Tokura, J. Misawa, H. Yagi, M. Takigawa, Erythrodermic cutaneous T‐cell lymphoma with CD8+CD56+ leukaemic T cells in a young woman, British Journal of Dermatology, Volume 149, Issue 4, 1 October 2003, Pages 891–893, https://doi.org/10.1046/j.1365-2133.2003.05533.x
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Sir, Cutaneous T‐cell lymphoma (CTCL) is a well‐recognized clinical entity encompassing mycosis fungoides, Sézary syndrome and other variants.1, 2 In the vast majority of CTCL cases, tumour cells have a CD4+ phenotype.2 However, patients with the CD8+ type have also been reported.3–6 Although the skin manifestations of CD8+ CTCL are heterogeneous, based on the clinical and pathological findings CD8+ CTCL can be categorized into the following clinical subtypes: (i) mycosis fungoides type,3 (ii) Sézary syndrome type,4 (iii) anaplastic large cell lymphoma or lymphomatoid papulosis,3 (iv) pagetoid reticulosis,5 and (v) rapidly progressive type.3, 6 We report a patient with erythrodermic CTCL whose malignant cells expressed CD56 as well as CD8.
A 26‐year‐old Japanese woman was referred in July 1999, for further evaluation of a skin eruption. She had noticed an asymptomatic erythematous plaque on her thigh at the age of 18 years. Her lesions had gradually increased in number and subsequently involved the trunk and all four extremities. She was diagnosed as having CTCL by histological examination and Southern blot analysis of lesional skin for T‐cell receptor (TCR) rearrangement. The eruption had gradually spread over almost the entire body surface thereafter. She had been treated with topical corticosteroid ointments and psoralen plus ultraviolet A therapy, and subsequently with intravenous recombinant interferon‐γ, but without benefit.
