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R. M. SCHWARTZMAN, A. M. KLIGMAN, D. D. DUCLOS, The Mexican hairless dog as a model for assessing the comedolytic and morphogenic activity of retinoids, British Journal of Dermatology, Volume 134, Issue 1, 1 January 1996, Pages 64–70, https://doi.org/10.1046/j.1365-2133.1996.d01-747.x
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Summary
The skin of the Mexican hairless dog is covered with comedones, and this animal therefore provides a potentially useful model to assess the comedolytic activity of topical anti‐acne drugs.
We treated an animal with three different formulations of tretinoin for a 14‐week period, and all produced a similar clinical response. There was a striking reduction in the number of comedones, and the skin became lighter and more uniform in colour. Histological changes were similar to those reported in humans treated with tretinoin, but a novel linding was incomplete neogenesis of hair follicles.
We suggest that the Mexican hairless dog may be a useful model for screening novel molecules for retinoid activity.