Summary

The skin of the Mexican hairless dog is covered with comedones, and this animal therefore provides a potentially useful model to assess the comedolytic activity of topical anti‐acne drugs.

We treated an animal with three different formulations of tretinoin for a 14‐week period, and all produced a similar clinical response. There was a striking reduction in the number of comedones, and the skin became lighter and more uniform in colour. Histological changes were similar to those reported in humans treated with tretinoin, but a novel linding was incomplete neogenesis of hair follicles.

We suggest that the Mexican hairless dog may be a useful model for screening novel molecules for retinoid activity.

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