EFFECTS OF LOW CONCENTRATIONS OF CYCLOPROPANE AND HALOTHANE ON PEAK VELOCITY OF SACCADIC EYE MOVEMENTS Free

We have investigated the effect of 4.7 and 8.8% MAC of cyclopropane, and 5.3 and 9.3% MAC of halothane on the peak velocity of saccadic eye movements (PSV) in six healthy volunteers. Both concentrations of cyclopropane and halothane significantly depressed PSV (P < 0.01) compared with air, in a dose-related fashion. Halothane depressed PSV significantly more than cyclopropane (P < 0.05). PSV returned to baseline within 5 min after discontinuation of the agents. There was no significant difference between cyclopropane, halothane and air in subjective assessment of sedation.