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Combination therapy is commonly employed in aesthetic medicine. The benefit of this approach may include a greater degree of improvement in the clinical feature being treated because of multiple inputs working by either the same mechanism or the complimentary mechanisms. Rather than using a single modality to the maximum extent, 2 modalities at lower levels may provide a safety margin to avoid complications. On the other hand, combining 2 modalities to amplify a single type of response could just as well be less safe rather than more so. The authors investigate 2 well-established treatments in aesthetic medicine, both of which stimulate neocollagenesis for skin rejuvenation, among other types of tissue remodeling. Existing medical literature was systematically reviewed to determine whether the clinical improvement is greater for a combined treatment than a stand-alone treatment and whether such a combination is safe.1

Microfocused ultrasound (MFUS) has specific FDA clearances both for skin lifting in the brow and submental/neck area as well as for improvement of lines and wrinkles in the décolletage.2 The healing response induced by the fractionated coagulation injuries produces neocollagenesis and tissue remodeling. Attempts to scale or amplify this effect have been frustratingly difficult to achieve.

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Research
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Commentary
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