Extract

Lonafarnib is a farnesyltransferase inhibitor.

Class: 92:92 • Other Miscellaneous Therapeutic Agents (AHFS primary) Brands: Zokinvy®

Uses

Lonafarnib has the following uses:

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Lonafarnib has the following limitations of use:

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Dosage and Administration

General.

Lonafarnib is available in the following dosage form(s) and strength(s):

Capsules: 50 mg and 75 mg

Dosage.

It is  essential  that the manufacturer’s labeling be consulted for more detailed information on dosage and administration of this drug. Dosage summary:

Pediatric Patients.

Dosage and Administration in Pediatric Patients 12 Months of Age and Older.

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Adults.

Dosage and Administration.

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Cautions

Contraindications.

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Warnings/Precautions.

Risk of Reduced Efficacy or Adverse Reactions Due to Drug Interactions.

Coadministration of lonafarnib with other drugs may result in clinically significant drug interactions. These drug interactions can lead to:

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See the manufacturer’s labeling for instructions on preventing or managing these clinically significant drug interactions, including dosage recommendations. Consider the potential for drug interactions prior to and during lonafarnib therapy; review concomitant medications during lonafarnib therapy; and monitor for the adverse reactions.

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