-
Views
-
Cite
Cite
Abstract from the Chinese Journal of Hypertension, American Journal of Hypertension, Volume 31, Issue 4, April 2018, Page 512, https://doi.org/10.1093/ajh/hpy017
Close - Share Icon Share
Extract
The Effects of Renal Sympathetic Denervation on Hypothalamic Mitogen-Activated Protein Kinase and NF-κB in Spontaneously Hypertensive Rats
Li Wang,1 Cheng-zhi Lu,1 Yi-jie Ma,1 Meng-ping Xv,1 Zhu-qing Li,1 and Chao Li1
1Department of cardiology, Tianjin First Center Hospital, Tianjin, China.
Correspondence: Cheng-zhi Lu ([email protected]).
Objective: To study the effects of renal sympathetic denervation (RDN) on blood pressure, hypothalamic mitogen-activated protein kinase (MAPK), and nuclear factor-kappa B (NF-κB) in spontaneously hypertensive rats (SHR).
Methods: Thirty-six SHR were randomly divided into baseline, RDN, and sham-operated groups (n = 12 rats per group). Age-matched Wistar-Kyoto (WKY) rats served controls (n = 12). At 12 weeks of age, rats underwent RDN or sham surgery and were killed after 1 or 6 weeks after surgery. Blood pressure, plasma levels of neuron-specific enolase (NSE), and p-p38MAPK, p65 NF-κB in the hypothalamus were assessed.
Results: At 1 to 5 weeks after RDN, systolic and diastolic blood pressures were significantly decreased. Compared with sham surgery at 1 week and SHR baseline, blood pressure was significantly decreased at 1 week after RDN (all P < 0.05). At 6 weeks after surgery, there were no statistical differences in the blood pressure among RDN, sham surgery and SHR baseline groups (all P > 0.05). Plasma NSE levels were increased in SHR baseline compared to WKY and were further increased 1 week after RDN (P < 0.05). Phosphorylation of p38 MAPK and p65 NF-κB proteins levels in the hypothalamus were increased in SHR groups compared to WKY controls and were decreased 1 week after RDN compared to SHR baseline (all P < 0.05).
