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Michael F. O'Rourke, Generation of Accurate Aortic Pressure Waves From Calibrated Upper Limb Pressure Waveforms, American Journal of Hypertension, Volume 24, Issue 12, December 2011, Page 1266, https://doi.org/10.1038/ajh.2011.185
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Fourteen years ago, Chen Chen-Huan et al. from Baltimore1 were the first to validate use of a transfer function method for generation of the aortic from the radial artery pressure waveform. This technique had the potential capacity to link the century old brachial cuff sphygmomanometer with the even older clinical method of palpating or directly recording the radial arterial pressure wave. There was a clear prospect of merging the two so as to generate central aortic pressure, as a simple procedure in a physician's office.
Such a view has been under attack and scrutiny since. In the process of different investigations, which entailed measurements of intra-arterial and cuff pressures in the aorta and upper limb, it became apparent that the greatest inaccuracy in using any method to generate central pressure was the difference—often vast—between cuff and intra-arterial pressure in the upper limb. This problem is intrinsic to the cuff and has not been overcome. Hopefully it will, and soon.
