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Helen Triantafyllidi, Stavros Tzortzis, John Lekakis, Ignatios Ikonomidis, Chrysa Arvaniti, Paraskevi Trivilou, Konstantinos Kontsas, Nikolaos Siafakas, Loukia Zerva, Eleftherios Stamboulis, Dimitrios Kremastinos, Maria Anastasiou-Nana, Association of Target Organ Damage With Three Arterial Stiffness Indexes According to Blood Pressure Dipping Status in Untreated Hypertensive Patients, American Journal of Hypertension, Volume 23, Issue 12, December 2010, Pages 1265–1272, https://doi.org/10.1038/ajh.2010.156
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Abstract
Subclinical organ damage represents an intermediate stage in the continuum of vascular disease and a determinant of overall cardiovascular risk. We investigated the associations of pulse wave velocity (PWV), ambulatory arterial stiffness index (AASI), and office pulse pressure (PP) with several target organ damages (TODs) in newly diagnosed and never-treated patients with essential hypertension with respect to their dipping profile.
One hundred sixty-eight hypertensive patients with recently diagnosed and never-treated stage I–II essential hypertension were evaluated with respect to the relationship of PWV, AASI, and office PP with TOD including microalbumin (MAU) levels, cognitive function, intima-media thickness (IMT), coronary flow reserve (CFR), left ventricular mass (LVM), left ventricular filling pressures, diastolic dysfunction, and left atrium (LA) enlargement.
Simultaneous estimation of AASI, PWV, and office PP independently associated with the following: (i) CFR (P < 0.01), 24-h urine albumin excretion rates (P < 0.05), left ventricular diastolic dysfunction (P < 0.01), and LA enlargement (P < 0.01) in never-treated hypertensive patients; (ii) CFR (P < 0.05), IMT (P < 0.01), left ventricular diastolic dysfunction (P < 0.05), and LA enlargement (P < 0.05) in dippers; and (iii) CFR (P < 0.05) and LA enlargement (P < 0.01) in nondippers. Nonindependent relationships revealed between (i) AASI and left ventricular filling pressures and (ii) PWV and cognitive dysfunction in never-treated hypertensive patients.
The simultaneous estimation of three noninvasive indexes of arterial stiffness leads to valuable information regarding their association with TOD including CFR, MAU levels, IMT, left ventricular diastolic dysfunction, and LA enlargement in never-treated hypertensive patients regarding their dipping status.
- hypertension
- intima media thickness
- left atrial hypertrophy
- excretory function
- heart disease risk factors
- albumins
- hypertension, essential
- left ventricle
- blood pressure
- pressure-physical agent
- urine
- cognitive impairment
- end organ damage
- arterial stiffness
- left ventricular diastolic dysfunction
- pulse wave velocity