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Malik A. Al-Omari, Mahyar Khaleghi, Thomas H. Mosley, Stephen T. Turner, Nils G. Morgenthaler, Joachim Struck, Andreas Bergmann, Iftikhar J. Kullo, Mid-Regional Pro-Adrenomedullin Is Associated With Pulse Pressure, Left Ventricular Mass, and Albuminuria in African Americans With Hypertension, American Journal of Hypertension, Volume 22, Issue 8, August 2009, Pages 860–866, https://doi.org/10.1038/ajh.2009.82
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Abstract
African Americans with hypertension are prone to target-organ damage and adverse cardiovascular events. Biomarkers for early detection of target-organ damage in this ethnic group are needed. Adrenomedullin (ADM) is a circulating vasoactive peptide with vasodilatory and antiproliferative effects that has been reported to be elevated in adults with hypertension.
We investigated the associations of plasma levels of mid-regional pro-ADM (MR-proADM) with pulse pressure, left ventricular mass (LVM), and albuminuria in 1,034 African-American adults (65 ± 9 years, 72% women) with hypertension. MR-proADM was measured by an immunoluminometric assay, LVM was assessed by 2-dimensional echocardiography, and albuminuria was assessed by urine albumin:creatinine ratio (UACR). Multivariable regression analyses were used to assess whether plasma MR-proADM was independently associated with pulse pressure, LVM indexed by height to the power 2.7 (LVMi), and UACR.
Plasma MR-proADM was significantly correlated (P < 0.001) with pulse pressure, LVMi, and UACR. In separate multivariable linear regression models that adjusted for age and sex, log MR-proADM was associated with greater pulse pressure (P = 0.007), log LVMi (P = 0.001), and log (UACR+1) (P < 0.0001). After additional adjustment for body mass index (BMI), total and high-density lipoprotein (HDL) cholesterol, smoking history, diabetes, estimated glomerular filtration rate (eGFR), history of myocardial infarction (MI) or stroke, and medication use, log MR-proADM remained significantly associated with greater pulse pressure (P = 0.001), log LVMi (P = 0.029), and log (UACR+1) (P = 0.002).
In African-American adults with hypertension, plasma MR-proADM is independently associated with pulse pressure, LVMi, and albuminuria and is a potential biomarker for target organ damage.
American Journal of Hypertension 2009; 22:860–866 © 2009 American Journal of Hypertension, Ltd.
- smoking
- hypertension
- body mass index procedure
- diabetes mellitus
- cerebrovascular accident
- albumins
- ischemic stroke
- left ventricle
- diabetes mellitus, type 2
- creatinine
- adult
- plasma
- urine
- drug usage
- pulse pressure
- urine albumin/creatinine ratio
- african american
- megalencephalic leukoencephalopathy with subcortical cysts
- albuminuria
- mid-regional pro-adrenomedullin