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Tetsuo Nakata, Kazuo Takeda, Hiroshi Itho, Masahiro Hirata, Shingo Kawasaki, Junko Hayashi, Minako Oguro, Susrimu Sasaki, Masao Nakagawa, Paraventricular Nucleus Lesions Attenuate the Development of Hypertension in DOC A/Salt-Treated Rats, American Journal of Hypertension, Volume 2, Issue 8, August 1989, Pages 625–630, https://doi.org/10.1093/ajh/2.8.625
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Abstract
To determine whether paraventricular nucleus (PVN) can play a role in the hypertension in DOCA/salt-treated rats, DOCA/salt hypertension was produced in PVN lesions and sham-operated rats. In lesioned rats, the development of hypertension was significantly attenuated (day 7 : 132 ± 3 ν 157 ± 5 mm Hg, P < 0.01; day 14 : 132 ± 3 ν 157 ± 5 mm Hg, P < 0 . 01 ; day 21: 189 ± 2 ν 224 ± 6 mm Hg, P<0.01). Lesions lowered systolic blood pressure in even control rats. Mean blood pressure (mBP) from awake free moving rats was also significantly lower in lesioned DOCA/salt-treated rats than those of sham-operated DOCA/salt-treated rats (155 ± 14 mm Hg ν 193 ± 13, P < 0.01 ) , while mBP was not different between lesioned and sham-operated control rats. The reduction of mBP by hexamethonium injections was significantly larger in sham-operated DOCA/salt-treated rats than those of lesioned DOCA/salt rats. ( -53 ± 3% ν -45 ± 2, P< 0.05). Plasma norepinephrine and epinephrine were significantly elevated in DOCA/salt-treated rats, however, PVN lesions inhibited significantly those elevations. 1-Deaminopenicillamine, 4-valine, 8-D-arginine Vasopressin (dPVDAVP) injections did not affect BP and heart rate in all rats. Body weight, water intake, urine volume, urine Na, K, and vasopressin excretion, and urine osmorality were not altered by lesions. These findings suggest that PVN contributes to development of hypertension in DOCA//salt-treated rats with sympathetic nervous activations. Am J Hypertens 1989;2:625-630