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Abstract

Alterations in Na, K ATPase pump activity as well as erythrocyte (RBC) intracellular sodium concentration (Nai) have been demonstrated in humans and rats with established hypertension. The contribution of hypertension itself to these changes is unclear. Accordingly, we investigated RBC ion transport and plasma ouabain-like factor (OLF) in four-to five-week old normotensive Dahl saltsensitive (DS) and salt-resistant (DR) rats on low salt diet. Although both strains were normotensive, systolic blood pressure (SBP) of DS (123 ± 2 mm Hg) was higher than that of DR (116 ± 1 mm Hg). No interstrain difference was evident in RBC pump activity measured as ouabain-sensitive 86rubidium (86Rb) uptake (DS = 0.277 ± .030 and DR = 0.271 ± .029 //mol/109RBC/h) even though RBC Naf was greater in DS than DR (14.9 ± 2.0 ν 10.7 ± 1.0 mEq/L; P < 0.05). Plasma OLF was higher in DS than DR (28.9 ± 4.7 ν 16.5 ± 2.3 pmol/mL; P < 0.05), but did not correlate with RBC pump activity in either strain. RBC Nai was directly correlated with pump activity in DS (r = 0.84, P < 0.01) and demonstrated a trend to correlate in DR (r = 0.71, P = 0.07). RBC Nai was also directly correlated with SBP in DR (r = 0.73, P < 0.05) and DS (r = 0.70, P = 0.05). We conclude that RBC Nai is genetically determined in Dahl rats and is elevated in normotensive DS who are at risk for hypertension development. The direct correlation between SBP and Nai in weanling DR and DS also suggests that RBC Nai is related to determinants of resting blood pressure. Thus, elevated SBP of prehypertensive DS may be predicted by their higher RBC Nai Am J Hypertens 1989;2:604-609

Ion transport, Dahl rats, ouabain-like factor, sodium-potassium ATPase, erythrocyte sodium concentration
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© American Journal of Hypertension, Inc. 1989
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ORIGINAL CONTRIBUTIONS
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