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Sinda B. Dianzumba, Donald DiPette, Claude R. Joyner, Effect of Age on Left Ventricular Filling in Children of Hypertensive Parents, American Journal of Hypertension, Volume 2, Issue 10, October 1989, Pages 792–796, https://doi.org/10.1093/ajh/2.10.792
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Abstract
Doppler transmitral flow velocity A/E ratio is a useful noninvasive estimate of left ventricular (LV) filling. However, the A/E ratio increases with age. To evaluate the effect of age on LV filling in children, Doppler transmitral flow velocity A/E ratios and echocardiographic measurements were obtained in 51 normal children (mean age 12 ± 4 years) of hypertensive parents (study children), sexand age-matched against 28 normal children (mean age 12 ± 4 years) from normotensive parents (control children). There was a significant correlation between age and LV systolic and diastolic internal dimensions (r = 0.74 and 0.83, respectively, P < .0001, in study children, and r = 0.70 and 0.79, respectively, P < .0001, in control children), total wall thickness (r = 0.72, P < .0001, in study children, and 0.61, P < .001, in control children), and with LV mass index (r = 0.56, P < .0001 and r = 0.45, P < .02, respectively). In contrast, there was no correlation between age and transmitral flow velocity A/E ratio in either group (r = 0.12 and 0.07, respectively). In conclusion, age does not have an effect on LV filling in normal children from either normotensive or hypertensive parents. Therefore, age correction of A/E ratio, which is necessary in adults, is not required in children. Because of a strong correlation between age and LV mass as well as LV mass index, age should be taken into account when defining criteria for LV hypertrophy in children. Am J Hypertens 1989;2:792–796.
