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John A. Papadakis, George Vrentzos, Irene Kazakou, Sylvia Lazaridou, Argiro Repa, Emmanouel S. Ganotakis, P-510: Lipid profile of patients with Isolated Systolic Hypertension, American Journal of Hypertension, Volume 18, Issue S4, May 2005, Page 192A, https://doi.org/10.1016/j.amjhyper.2005.03.527
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Abstract
Isolated Systolic Hypertension (ISH) has been shown to increase cardiovascular disease morbidity and mortality. In this study, we searched for differences in the lipid profile between subjects with ISH and those with essential hypertension.
We studied 442 [212 (48%) were men] hypertensives, who had never been treated. Their median age was 56 (range: 18–83) years. Among them, 135 (30.5%) patients had ISH [Systolic Blood Pressure (SBD) > 140mmHg and Diastolic Blood Pressure (DBP) < 90mmHg]. All patients had a full lipid profile.
Persons with ISH were older than other hypertensives (62.0±10.8 vs 53.4±11.9 years, p<0.001). There was no difference in the sex distribution between the two groups [66 out of 135 (48.9%) vs 146 out of 307 (47.6%) were men, respectively]. Those with ISH had significantly greater pulse pressure (PP) (71.6±16.1 vs 60.6±16.8 mmHg, p<0.001) and significantly smaller body mass index (BMI) (29.3±3.9 vs 30.9±5.2, p<0.01), when compared with the rest hypertensives.
Subjects with ISH had significantly higher high density lipoprotein (HDL) than the rest hypertensives (51.8±17.6 vs 46.9±11.6mg/dl; p<0.01). There were no other significant differences in the rest lipid profile between the two groups.
In conclusion, our study suggests that among untreated patients with essential hypertension those with ISH had a more favourable lipid profile.