-
Views
-
Cite
Cite
Christian Delles, Markus P. Schneider, Stefan John, Michael Gekle, Roland E. Schmieder, Angiotensin Converting Enzyme Inhibition and Angiotensin II AT1-Receptor Blockade Reduce the Levels of Asymmetrical NG, NG-Dimethylarginine in Human Essential Hypertension, American Journal of Hypertension, Volume 15, Issue 7, July 2002, Pages 590–593, https://doi.org/10.1016/S0895-7061(02)02278-1
Close - Share Icon Share
Abstract
Asymmetrical NG, NG-dimethylarginine (ADMA) is associated with impaired endothelium-dependent vasodilation in humans.
Twenty young, male, mildly hypertensive subjects were included in a randomized, double-blind, fourfold cross-over study with placebo, enalapril (20 mg/day), eprosartan (600 mg/day), or a combination of both drugs (10 and 300 mg/day, respectively) each over 1 week, followed by a 2-week wash-out phase. After each treatment phase, ADMA concentration was measured.
ADMA concentration was 1.69 ± 0.59 μmol/L in the placebo phase, and was significantly lower in the enalapril, eprosartan, and combination phases (1.41 ± 0.29, 1.42 ± 0.43, and 1.38 ± 0.30 μmol/L, respectively; all P < 0.05 v placebo). Changes in ADMA levels were independent of the drugs’ action on blood pressure (BP).
Levels of ADMA were reduced with enalapril and eprosartan therapy. Our results suggest a specific action of these drugs on ADMA levels that is independent of BP.
