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Abstract

Microalbuminuria is an independent cardiovascular risk factor in hypertensive patients. Diabetics most often display micro-and macroalbuminuria, while the controlling factors in non-diabetic hypertensives are explored in this paper. We studied 2700 consecutive untreated patients with uncomplicated arterial hypertension. Diabetics were excluded, and in dubious cases glucose tolerence tests were done. Urinary albumin excretion was measured in 24hour urinary collection. The mean microalbumin value was 29.5±28.9 mg/L, while 44.1% patients had values over 20 mg/L. Patients were grouped according to selected characteristics, as below. (See Table)

FactornYESNOpr valuep
Males148631,0 ± 32,927,7 ± 25,40,0060,0540,005
Smoking101732,6 ± 31,927,7 ± 40,00,0010,080<0,0001
Obesity146531,0 ± 30,527,8 ± 28,80,0090,086<0,0001
↑ Waist/Hips141535,4 ± 32,623,0 ± 24,7<0,00010,177<0,0001
>55 years old99333,1 ± 31,327,4 ± 28,6<0,00010,127<0,0001
Dyslipidaemia94833,7 ± 27,127,2 ± 30,9<0,00010,106<0,0001
High PRA117036,8 ± 32,024,0 ± 26,6<0,00010,130<0,0001
LVH141635,5 ± 32,822,9 ± 24,3<0,00010,275<0,0001
FactornYESNOpr valuep
Males148631,0 ± 32,927,7 ± 25,40,0060,0540,005
Smoking101732,6 ± 31,927,7 ± 40,00,0010,080<0,0001
Obesity146531,0 ± 30,527,8 ± 28,80,0090,086<0,0001
↑ Waist/Hips141535,4 ± 32,623,0 ± 24,7<0,00010,177<0,0001
>55 years old99333,1 ± 31,327,4 ± 28,6<0,00010,127<0,0001
Dyslipidaemia94833,7 ± 27,127,2 ± 30,9<0,00010,106<0,0001
High PRA117036,8 ± 32,024,0 ± 26,6<0,00010,130<0,0001
LVH141635,5 ± 32,822,9 ± 24,3<0,00010,275<0,0001
FactornYESNOpr valuep
Males148631,0 ± 32,927,7 ± 25,40,0060,0540,005
Smoking101732,6 ± 31,927,7 ± 40,00,0010,080<0,0001
Obesity146531,0 ± 30,527,8 ± 28,80,0090,086<0,0001
↑ Waist/Hips141535,4 ± 32,623,0 ± 24,7<0,00010,177<0,0001
>55 years old99333,1 ± 31,327,4 ± 28,6<0,00010,127<0,0001
Dyslipidaemia94833,7 ± 27,127,2 ± 30,9<0,00010,106<0,0001
High PRA117036,8 ± 32,024,0 ± 26,6<0,00010,130<0,0001
LVH141635,5 ± 32,822,9 ± 24,3<0,00010,275<0,0001
FactornYESNOpr valuep
Males148631,0 ± 32,927,7 ± 25,40,0060,0540,005
Smoking101732,6 ± 31,927,7 ± 40,00,0010,080<0,0001
Obesity146531,0 ± 30,527,8 ± 28,80,0090,086<0,0001
↑ Waist/Hips141535,4 ± 32,623,0 ± 24,7<0,00010,177<0,0001
>55 years old99333,1 ± 31,327,4 ± 28,6<0,00010,127<0,0001
Dyslipidaemia94833,7 ± 27,127,2 ± 30,9<0,00010,106<0,0001
High PRA117036,8 ± 32,024,0 ± 26,6<0,00010,130<0,0001
LVH141635,5 ± 32,822,9 ± 24,3<0,00010,275<0,0001

It is concluded that high renin male patients burdened with smoking, obesity, dyslipidemia and left ventricular hypertrophy are more often microalbuminurics.

Microalbuminuria, Non-diabetics patients, Essential hypertension
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© American Journal of Hypertension, Ltd. 2001
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